Behavioural and electrophysiological correlates of synaptopathy

Jonatan Märcher-Rørsted

Noise-induced hearing loss is a significant public health problem in industrialized nations across the world. Until recently, noise exposures that only temporarily reduce hearing thresholds were not considered hazardous. Yet, an increasing number of patients seeking audiological help are found to have normal hearing sensitivity in standard clinical tests. Recent research has suggested, that such ”hidden” hearing-loss can be attributed to dysfunction of synapses in the inner-ear, also known as synaptopathy.

The project is part of the international Uncovering Hidden Hearing Loss synergy project ( UHEAL ) focused on diagnosis of synaptopathy and understanding it’s perceptual consequences in auditory behavior. Other parts of the UHEAL project identifies cellular changes in damaged ears using animal physiology and microstructure imaging. The current PhD project then focuses on detecting behavioral and electrophysiological correlates of synaptopathy in human listeners that are also examined in other parts of the project.

Supervisors: Torsten Dau, Jens Hjortkjær (DTU)

To be completed in 2021

DTU Orbit

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Jonatan Märcher-Rørsted
PhD student
DTU Health Tech